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A Novel Method Using Dual-Energy Computed Tomography for Detecting Amiodarone-Induced Lung Injury: A Cohort Pilot Study
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March 2026
Authors: Naama R. Bogot, Ariel Rokach, Irith Hadas-Halperen, Yehonatan Cohen, Ayal Romem, Moshe Rav-Acha, Tal Hasin, Gabriel Izbicki, Nissim Arish
Comment by Mark Lavercombe: Diagnosing amiodarone-induced lung disease (AILD) requires a combination of clinical, radiologic and physiologic findings, and exclusion of other potential diagnoses. Due to the presence of iodine in amiodarone, the researchers in this study evaluated whether dual-energy computed-tomography (DECT) would demonstrate iodine deposition in the lung and liver. Their cohort included 83 patients with suspected AILD, although two were excluded due to breathing artefact. The average amiodarone dose in the 81 included patients was 210 ± 53 (100–400) mg/day, with a treatment duration of 29 ± 25 (1–156) months. 24 patients were considered high clinical probability for AILD, and the remainder classed as low. There was substantial correlation between radiologic and clinical probability of AILD [Cohen’s k = 0.61 (CI: 0.41–0.80), p < 0.001].
Medical Education Editor for Respirology
Dr Mark Lavercombe was appointed in this specialist editor role in 2021 to further expand and strengthen Respirology’s contribution to medical education.
Located in Melbourne, Australia, he works as a clinician in respiratory health and sleep disorders at Western Health and is affiliated with The University of Melbourne as a distinguished expert in medical education.
He became a member of our Editorial Board in 2016 with the responsibility of selecting new Respirology publications with educational value, which has grown into a curated article selection featured on this page, as a benefit to APSR members.
Dr Lavercombe also authors a column in Respirology on his most recent choices and their specific value to continued medical education for our readers around the world.
