Education&ScienceEducational Article

Clinical Presentation and Diagnostic Evaluation of Vaping Related Lung Injury in Youth

July 2025

Authors: Eleanor D. Muise, Rachel Gordon, Jacqueline Steiding, Keri Sullivan, Catherine A. Sheils, Alicia M. Casey

Comment by Mark Lavercombe: In the twenty-two years since the invention of the first modern e-cigarette, there has been an explosion in the available devices and liquids. Jurisdictions have applied different approaches to e-cigarette use, from embracing them as a harm minimisation strategy for nicotine-addicted cigarette smokers to requiring a medical prescription. The e-cigarette or vaping product use-associated lung injury (EVALI) outbreak in 2019 in the United States (USA) led to a renewed focus on the risks of these devices. In the current paper, the authors describe a comprehensive, multidisciplinary approach to patients who are vaping, aged 10-35 years, in Boston, USA, and suspected of lung injury. They report a significant prevalence of EVALI, including in their outpatients, and highlight the value of their interdisciplinary approach to diagnosis and treatment.